Education

2013 Spring Term

• Previous Semester Courses
• Independent Study

GENOME 156 - 01/BIO 156 - 01 Genetics, Genomics, and Society: Implications for the 21st Century
Alison Hill
TuTh 3:05PM - 4:20PM
Introduction to the foundation of genomic sciences with an emphasis on recent advances and their social, ethical and policy implications. Foundational topics including DNA, proteins, genome organization, gene expression, and genetic variation will be interwoven with contemporary issues emanating from the genome revolution such as pharmacogenetics, genetic discrimination, genomics of race, genetically modified crops, and genomic testing. Genomic sciences and policy science applied to present and future societal, and particularly ethical, concerns related to genomics. Intended for non-Biology majors. Not open to students who have taken Biology 210FS, 201L or 202L.

GENOME 159 - 01/BIO 159 - 01 The Past and Future of the Human Genome
David Goldstein, Elizabeth Cirulli, Misha Angrist
MW 3:05PM - 4:20PM
Exploration of current DNA technology and potential impacts which are in continual flux because of new scientific findings, medical advances, judicial rulings. Introduction to the structure of the genome, genetic variation, and the genetic basis of disease to study existing and future medical, ethical, and policy issues. Intended for non-majors.

GENOME 238S - 01/PUBPOL 233S - 01 Influential Scientists and Policy Leaders in Science Policy
Susanne Haga
Th 1:25PM - 3:55PM
Explores role of scientist and non-scientist policy-makers and elected officials who have substantially shaped U.S. science research and application of scientific discoveries throughout the 20th century from within and outside the federal government. Science policies examined in larger context of political, cultural, and social events.

GENOME 256 - 01 Genome Sciences and Society
Misha Angrist
MW 10:05AM - 11:20AM
Parallels Genome 156. Focus on contemporary study of human genome with particular attention given to relationships among structural and functional genomics, genome variation and phenotypic variation. Incorporates discussion of social and policy issues created by the Genome Revolution. Students will develop a final paper addressing the science and societal impact of a genomics topic. Prerequisites: Biology 201L/202L or Biology 210FS or consent of instructor.

GENOME 498S - 01 Genome Sciences and Policy Capstone
Huntington Willard, Robert Cook-Deegan
Tu 6:15PM - 8:45PM
Create and apply knowledge gained through certificate course work and research experiences in an intensive, interdisciplinary, small group setting. Students work in small teams learning to analyze current issues in genome sciences and policy and to consider the issue from scientific, social, and ethical perspectives. Teams will present their research as an oral final project. Open only to graduating seniors in the Genome Sciences and Policy program or by consent of instructor.

GENOME 590S-1 - 01/AAAS 690S - 01 Integrative Study of the African Diaspora
Charmaine Royal
TuTh 11:45AM - 1:00PM
Seminar version of African and African American Studies 299.

PHIL 218 - 01 Philosophical Issues in Medical Ethics
Jennifer Hawkins
MW 1:25PM - 2:40PM
Ethical issues arising in connection with medical practice and research and medical technology. Definition of health and illness; experimentation and consent; genetic counseling and biological engineering; abortion, contraception, and sterilization; death and dying; codes of professional conduct; and the allocation of scarce medical resources. Prerequisite: for freshmen, previous philosophy course and consent of instructor.

CBB 612 - 01/GENOME 612 - 01/PUBPOL 634 -01 Responsible Genomics *
Subhashini Chandrasekharan
TuTh 3:05PM - 4:20PM
Survey of ethical, social, economic, and legal issues in genomics. Introduction to ethical reasoning and examination of selected issues calling for such analysis, including: special procedures for research involving human participants, (2) respect for privacy and confidentiality of genetic information; (3) historical and political background of health research funding, and (4) public-private research interactions such as intellectual property and conflict of interest.

BIOLOGY 311 - 01 Systems Biology: An Introduction for the Quantitative Sciences
Amy Schmid, Paul Magwene
TuTh 3:05PM - 4:20PM
Introduction to concepts and applications of Systems Biology. Identification of molecular interactions that underlie cellular function using high dimension data acquired through high-throughput approaches. Intended for students with prior training in quantitative fields (computer science, math, physics, statistics, engineering).

BIOLOGY 350 - 01/UPGEN 787-01 Complex Traits and Evolutionary Genetics
John Mercer
TuTh 3:05PM - 4:20PM
Introduction to the principles of evolutionary genetics and variation of complex phenotypic traits. Genetic variation, neutral theory, natural selection, quantitative genetics, human population genetics, phylogenetic reconstruction, evolutionary genomics, and evolutionary bioinformatics. Prerequisites: Biology 20 or 202L.

CBB 662 - 01/COMPSCI 662 -01 Computational Systems Biology *
Alexander Hartemink
TuTh 10:05AM - 11:20AM
Provides a systematic introduction to algorithmic and computational issues present in the analysis of biological systems. Emphasizes probabilistic approaches and machine learning methods. Explores modeling basic biological processes (e.g., transcription, splicing, localization and transport, translation, replication, cell cycle, protein complexes, evolution) from a systems biology perspective. Lectures and discussions of primary literature. Prerequisites: basic knowledge of algorithm design (Computer Science 530 or equivalent), probability and statistics (Statistical Science 611 or equivalent), molecular biology (Biology 201L or equivalent), and computer programming. Alternatively, consent of instructor.

ENVIRON 590 - 105/GENOME 590S -01 Questions in Ecological Genomics *
Jennifer Wernegreen
M 3:05PM - 5:40PM
In this seminar course, we will explore how genomics is influencing research in ecology and environmental biology. The widened accessibility of genomic techniques, particularly 'next-generation' approaches, has generated the new field of ecological genomics. Focusing on recent case studies in the primary literature, we will ask whether genomic data let us address key biological questions in novel and significant ways. Students will select the specific case studies and primary articles we discuss. To obtain a permission number or for more information, please contact Jen Wernegreen at j.wernegreen@duke.edu or 681-0331.

LAW 584 - 01 Genetics and Reproductive Technologies *
Nita Farahany
Tu 1:30PM - 3:20PM
This course will examine the complex interrelationship between legal, political, ethical, and social issues shaping the intersection of genetics, reproductive technologies and reproductive rights. Course will be graded based upon papers and class participation.

PHARM 370S - 01 Pharmacogenomics and Personalized Medicine
Thomas Urban
MW 3:05PM - 4:20PM
Introduction to human genetic and genomics and how the topics relate to modern medicine and treatment. Special emphasis placed on principles of human genomics (including human genome organization, complex disease and large scale genomic analysis) and how they relate to the field of translational genomics (bridging human genetics to drug design). Discussion of ethical and societal issues concerning personalized medicine as well as future implications to modern health care. Current journal articles highlighting new genomic treatments will be presented and discussed

*Course open to graduate students and advanced undergraduates with instructor's consent.