Why does melanoma metastasize into the brain? Genes with pleiotropic effects might be the key.
Yashin AI, Wu D, Arbeev KG, Kulminski AM, Stallard E, Ukraintseva SV, Front Genet. 2013;4:75. Abstract
IGSP Faculty
Alexander M. Kulminski, PhDAlexander M. Kulminski, PhD
Senior Research Scientist, Center for Population Health and Aging
Alexander Kulminski is a Senior Research Scientist at the Center for Population Health and Aging (CPHA) at Duke. He received his PhD in physics and applied mathematics in 1991 from the Institute of Physics of Belarus Academy of Sciences. After 15 years of his carrier in the field, he joined research team at Center for Demographic Studies at Duke in 2002 which was eventually transformed to the CPHA. Since that time, he has focused on multi- and interdisciplinary research of systemic determinants of health, aging, and lifespan by studying large-scale data collected in various longitudinal and cross-sectional studies in humans and non-human species. Systemic strategies are aimed to reveal intrinsic mechanisms of health deterioration with age and integrate different pieces of this complex puzzle,—often studied by different disciplines—, together. Mathematics, bio-demography, aging, geriatrics, gerontology, biology, epidemiology, and genetics are the disciplines which integration in the life course biogenetics is highly promising for fostering insights on aging-related processes in human beings and translation of these insights into practice.
Recent Publications
How lifespan associated genes modulate aging changes: lessons from analysis of longitudinal data.
Yashin AI, Arbeev KG, Wu D, Arbeeva LS, Kulminski A, Akushevich I, Culminskaya I, Stallard E, Ukraintseva SV, Front Genet. 2013;4:3. Abstract
The role of lipid-related genes, aging-related processes, and environment in healthspan.
Kulminski AM, Culminskaya I, Arbeev KG, Ukraintseva SV, Stallard E, Arbeeva L, Yashin AI, Aging Cell. 2013 Apr;12(2):237-46. Abstract
Biogenetic Mechanisms Predisposing to Complex Phenotypes in Parents May Function Differently in Their Children.
Kulminski AM, Arbeev KG, Christensen K, Stallard E, Miljkovic I, Barmada M, Yashin AI, J Gerontol A Biol Sci Med Sci. 2012 Dec 4;. Abstract
Trade-off in the effect of the APOE gene on the ages at onset of cardiocascular disease and cancer across ages, gender, and human generations.
Kulminski AM, Culminskaya I, Arbeev KG, Ukraintseva SV, Arbeeva L, Yashin AI, Rejuvenation Res. 2013 Feb;16(1):28-34. Abstract
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